Recent Publications
Involvement of Neuroinflammation in the Pathogenesis of Monocrotaline-Induced Pulmonary Hypertension. Sharma RK, Oliveira AC, Kim S, Rigatto K, Zubcevic J, Rathinasabapathy A, Kumar A, Lebowitz JJ, Khoshbouei H, Lobaton G, Aquino V, Richards EM, Katovich MJ, Shenoy V, Raizada MK. Hypertension. 2018 Jun;71(6):1156-1163. doi: 10.1161/HYPERTENSIONAHA.118.10934. PMID: 29712738
HIV-1 Tat regulation of dopamine transmission and microglial reactivity is brain region specific. Miller DR, Shaerzadeh F, Phan L, Sharif N, Gamble-George J, McLaughlin JP, Streit WJ, Khoshbouei H. Glia. 2018 May 7. doi: 10.1002/glia.23447. PMID: 29733459
Functional connectivity, behavioral and dopaminergic alterations 24 hours following acute exposure to synthetic bath salt drug methylenedioxypyrovalerone. Colon-Perez LM, Pino JA, Saha K, Pompilus M, Kaplitz S, Choudhury N, Jagnarine DA, Geste JR, Levin BA, Wilks I, Setlow B, Bruijnzeel AW, Khoshbouei H, Torres GE, Febo M. Neuropharmacology. 2018 May 3;137:178-193. doi: 10.1016/j.neuropharm.2018.04.031. PMID: 29729891
Glial cells modulate hippocampal synaptic plasticity in morphine dependent rats. Elahi-Mahani A, Heysieattalab S, Hosseinmardi N, Janahmadi M, Seyedaghamiri F, Khoshbouei H. Brain Res Bull. 2018 Apr 17;140:97-106. doi: 10.1016/j.brainresbull.2018.04.006. PMID: 29678774
Hippocampal glial cells modulate morphine-induced behavioral responses. Seyedaghamiri F, Heysieattalab S, Hosseinmardi N, Janahmadi M, Elahi-Mahani A, Salari F, Golpayegani M, Khoshbouei H. Physiol Behav. 2018 Jul 1;191:37-46. doi: 10.1016/j.physbeh.2018.04.003. Epub 2018 Apr 4. PMID: 29626506
The dopamine transporter: An unrecognized nexus for dysfunctional peripheral immunity and signaling in Parkinson's Disease. Mackie P, Lebowitz J, Saadatpour L, Nickoloff E, Gaskill P, Khoshbouei H. Brain Behav Immun. 2018 Mar 15. pii: S0889-1591(18)30071-0. doi: 10.1016/j.bbi.2018.03.020. PMID: 29551693
The sigma-1 receptor as a regulator of dopamine neurotransmission: A potential therapeutic target for methamphetamine addiction. Sambo DO, Lebowitz JJ, Khoshbouei H. Pharmacol Ther. 2018 Jan 29. pii: S0163-7258(18)30016-0. doi: 10.1016/j.pharmthera.2018.01.009.
The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission. Sambo D, Lin M, Owens A, Lebowitz J, Richardson B, Jagnarine D, Shetty M, Rodriguez M, Alonge T, Ali M, Katz J, Yan L, Febo M, Henry K, Bruijnzeel A, Dawes L, Khoshbouei H. Nat Commun. 2017 Dec 20;8(1):2228. doi:10.1038/s41467-017-02087-x. PMID: 29263318
Methamphetamine Regulation of Firing Activity of Dopamine Neurons. Lin M, Sambo D, Khoshbouei H. Journal of Neurosci. 2016 Oct 5;36(40):10376-10391. PMID: 27707972
Proteolysis of α-synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology. Sacino AN, Brooks MM, Chakrabarty P, Saha K, Khoshbouei H, Golde TE, Giasson BI. J Neurochem. 2017 Feb;140(4):662-678. doi: 10.1111/jnc.13743. Epub 2016 Aug 19. PMID: 27424880
Amphetamine Reverses Escalated Cocaine Intake via Restoration of Dopamine Transporter Conformation. Siciliano CA, Saha K, Calipari ES, Fordahl SC, Chen R, Khoshbouei H, Jones SR. J Neurosci. 2018 Jan 10;38(2):484-497. doi: 10.1523/JNEUROSCI.2604-17.2017. Epub 2017 Nov 24. PMID: 29175958
A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking. Khare S, Nick JA, Zhang Y, Galeano K, Butler B, Khoshbouei H, Rayaprolu S, Hathorn T, Ranum LPW, Smithson L, Golde TE, Paucar M, Morse R, Raff M, Simon J, Nordenskjöld M, Wirdefeldt K, Rincon-Limas DE, Lewis J, Kaczmarek LK, Fernandez-Funez P, Nick HS, Waters MF. PLoS One. 2017 May 3;12(5):e0173565. doi: 10.1371/journal.pone.0173565. eCollection 2017. PMID: 28467418
HIV, Tat and dopamine transmission. Gaskill PJ, Miller DR, Gamble-George J, Yano H, Khoshbouei H. Neurobiol Dis. 2017 Sep;105:51-73. doi: 10.1016/j.nbd.2017.04.015. Epub 2017 Apr 27. Review. PMID: 28457951
Alpha-synuclein modulates dopamine neurotransmission. Butler B, Sambo D, Khoshbouei H. J Chem Neuroanat. 2016 Jun 19. pii: S0891-0618(16)30068-0. doi: 10.1016/j.jchemneu.2016.06.001. [Epub ahead of print] Review. PMID: 27334403
Methamphetamine-induced enhancement of hippocampal long-term potentiation is modulated by NMDA and GABA receptors in the shell-accumbens. Heysieattalab S, Naghdi N, Hosseinmardi N, Zarrindast MR, Haghparast A, Khoshbouei H. Synapse. 2016 Aug;70(8):325-35. doi: 10.1002/syn.21905. Epub 2016 Apr 15. PMID: 27029021
Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membrane. Richardson BD, Saha K, Krout D, Cabrera E, Felts B, Henry LK, Swant J, Zou MF, Newman AH, Khoshbouei H. Nat Commun. 2016 Jan 25;7:10423. doi: 10.1038/ncomms10423. PMID: 26804245
The effects of GABAA and NMDA receptors in the shell-accumbens on spatial memory of METH-treated rats. Heysieattalab S, Naghdi N, Zarrindast MR, Haghparast A, Mehr SE, Khoshbouei H. Pharmacol Biochem Behav. 2016 Mar;142:23-35. doi: 10.1016/j.pbb.2015.12.008. Epub 2015 Dec 18. PMID: 26708956
Dopamine Transporter Activity Is Modulated by α-Synuclein. Butler B, Saha K, Rana T, Becker JP, Sambo D, Davari P, Goodwin JS, Khoshbouei H. J Biol Chem. 2015 Dec 4;290(49):29542-54. doi: 10.1074/jbc.M115.691592. Epub 2015 Oct 6. PMID: 26442590
Intracellular Methamphetamine Prevents the Dopamine-induced Enhancement of Neuronal Firing. Saha K, Sambo D, Richardson BD, Lin LM, Butler B, Villarroel L, Khoshbouei H J Biol Chem. 2014 Aug 8;289(32):22246-57. doi: 10.1074/jbc.M114.563056. Epub 2014 Jun 24.
The effect of manganese on dopamine toxicity and dopamine transporter (DAT) in control and DAT transfected HEK cells. Roth JA, Li Z, Sridhar S, Khoshbouei H. Neurotoxicology. 2013 Mar; 35: 121-8. doi: 10.1016/j.neuro.2013.01.002 Epub 2013 Jan 11.
Chronic methamphetamine exposure produces a delayed, long-lasting memory deficit. North A, Swant J, Salvatore MF, Gamble-George J, Prins P, Butler B, Mittal MK, Heltsley R, Clark JT, Khoshbouei H. Synapse. 2013 May;67(5):245-57. doi: 10.1002/syn.21635. Epub 2013 Feb. 8
Single cell measurement of dopamine release with simultaneous voltage-clamp and amperometry. Saha K, Swant J, Khoshbouei H. J Vis Exp. 2012 Nov 21;(69). pii: 3798. doi: 10.3791-3798.
α-Synuclein Stimulates a Dopamine Transporter-dependent Chloride Current and Modulates the Activity of the Transporter. Swant J, Goodwin JS, North A, Ali AA, Gamble-George J, Chirwa S, Khoshbouei H. J Biol Chem. 2011 Dec 23;286(51):43933-43. Epub 2011 Oct 11.
Methamphetamine reduces LTP and increases baseline synaptic transmission in the CA1 region of mouse hippocampus. Swant J, Chirwa S, Stanwood G, Khoshbouei H. PLoS One. 2010 Jun 30;5(6):e11382.
Amphetamine and methamphetamine differentially affect dopamine transporters in vitro and in vivo. Goodwin JS, Larson GA, Swant J, Sen N, Javitch JA, Zahniser NR, De Felice LJ, Khoshbouei H. J Biol Chem. 2009 Jan 30;284(5):2978-89. Epub 2008 Dec 1.
PI3K signaling supports amphetamine-induced dopamine efflux. Lute BJ, Khoshbouei H, Saunders C, Sen N, Lin RZ, Javitch JA, Galli A. Biochem Biophys Res Commun. 2008 Aug 8;372(4):656-61. Epub 2008 May 27.
Amphetamine induces dopamine efflux through a dopamine transporter channel. Kahlig KM, Binda F, Khoshbouei H, Blakely RD, McMahon DG, Javitch JA, Galli A. Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3495-500. Epub 2005 Feb 22.