Aurora kinase A inhibition plus Tumor Treating Fields suppress glioma cell proliferation in a cilium-independent manner Tian J, Mallinger JC, Shi P, Ling D, Deleyrolle LP, Lin M, Khoshbouei H, Sarkisian MR. Transl Oncol. 2024 Jul;45:101956. doi: 10.1016/j.tranon.2024.101956. Epub 2024 Apr 18. PMID: 38640786; PMCID: PMC11053227.

Development of a Fluorescently Labeled Ligand for Rapid Detection of DAT in Human and Mouse Peripheral Blood Monocytes Camacho-Hernandez GA, Gopinath A, Okorom AV, Khoshbouei H, Newman AH. JACS Au. 2024 Jan 24;4(2):657-665. doi: 10.1021/jacsau.3c00719. PMID: 38425927; PMCID: PMC10900201.

Immunity on ice: The impact of methamphetamine on peripheral immunity Miller EJ, Khoshbouei H. Immunity on ice: Adv Pharmacol. 2024;99:217-250. doi: 10.1016/bs.apha.2023.09.003. Epub 2023 Oct 24. PMID: 38467482.

Immunophenotyping Tracks Motor Progression in Parkinson's Disease Associated with a TH Mutation Gopinath A, Ramirez-Zamora A, Franks S, Riaz T, Smith A, Dizon G, Hornstein L, Follett J, Swartz C, Bravo J, Kugelmann EL, Farrer M, Okun MS, Khoshbouei H. J Parkinsons Dis. 2024;14(4):883-888. doi: 10.3233/JPD-240030. PMID: 38788089; PMCID: PMC11191508.

Asymmetric control of food intake by left and right vagal sensory neurons de Araujo AM, Braga I, Leme G, Singh A, McDougle M, Smith J, Vergara M, Yang M, Lin M, Khoshbouei H, Krause E, de Oliveira AG, de Lartigue G. bioRxiv [Preprint]. 2023 May 8:2023.05.08.539627. doi: 10.1101/2023.05.08.539627. PMID: 37214924; PMCID: PMC10197596.

Choroid plexus mis-splicing and altered cerebrospinal fluid composition in myotonic dystrophy type 1 Nutter CA, Kidd BM, Carter HA, Hamel JI, Mackie PM, Kumbkarni N, Davenport ML, Tuyn DM, Gopinath A, Creigh PD, Sznajder ŁJ, Wang ET, Ranum LPW, Khoshbouei H, Day JW, Sampson JB, Prokop S, Swanson MS. Brain. 2023 Oct 3;146(10):4217-4232. doi: 10.1093/brain/awad148. PMID: 37143315; PMCID: PMC10545633.

Clinical and pathological characterization of Central Nervous System cryptococcosis in an experimental mouse model of stereotaxic intracerebral infection Hamed MF, Enriquez V, Munzen ME, Charles-Niño CL, Mihu MR, Khoshbouei H, Alviña K, Martinez LR. PLoS Negl Trop Dis. 2023 Jan 19;17(1):e0011068. doi: 10.1371/journal.pntd.0011068. PMID: 36656900; PMCID: PMC9888703.

Complement C1q-dependent engulfment of alpha-synuclein induces ENS-resident macrophage exhaustion and accelerates Parkinson's-like gut pathology Mackie PM, Koshy J, Bhogade M, Hammoor T, Hachmeister W, Lloyd GM, Paterno G, Bolen M, Tansey MG, Giasson BI, Khoshbouei H. bioRxiv [Preprint]. 2023 Oct 28:2023.10.24.563832. doi: 10.1101/2023.10.24.563832. PMID: 37961460; PMCID: PMC10634831.

Inhibition of LRRK2 kinase activity rescues deficits in striatal dopamine physiology in VPS35 p.D620N knock-in mice Bu M, Follett J, Deng I, Tatarnikov I, Wall S, Guenther D, Maczis M, Wimsatt G, Milnerwood A, Moehle MS, Khoshbouei H, Farrer MJ. NPJ Parkinsons Dis. 2023 Dec 18;9(1):167. doi: 10.1038/s41531-023-00609-7. PMID: 38110354; PMCID: PMC10728137.

Methamphetamine induces a low dopamine transporter expressing state without altering the total number of peripheral immune cells Gopinath A, Riaz T, Miller E, Phan L, Smith A, Syed O, Franks S, Martinez LR, Khoshbouei H. Basic Clin Pharmacol Toxicol. 2023 Nov;133(5):496-507. doi: 10.1111/bcpt.13838. Epub 2023 Feb 16. PMID: 36710070; PMCID: PMC10382601.

Receptor-interacting protein kinase 2 (RIPK2) profoundly contributes to post-stroke neuroinflammation and behavioral deficits with microglia as unique perpetrators Larochelle J, Tishko RJ, Yang C, Ge Y, Phan LT, Gunraj RE, Stansbury SM, Liu L, Mohamadzadeh M, Khoshbouei H, Candelario-Jalil E. J Neuroinflammation. 2023 Sep 30;20(1):221. doi: 10.1186/s12974-023-02907-6. PMID: 37777791; PMCID: PMC10543871.

Role of Microglia in Psychostimulant Addiction da Silva MCM, Iglesias LP, Candelario-Jalil E, Khoshbouei H, Moreira FA, de Oliveira ACP. Curr Neuropharmacol. 2023;21(2):235-259. doi: 10.2174/1570159X21666221208142151. PMID: 36503452; PMCID: PMC10190137.

The complex role of inflammation and gliotransmitters in Parkinson's disease Gopinath A, Mackie PM, Phan LT, Tansey MG, Khoshbouei H. Neurobiol Dis. 2023 Jan;176:105940. doi: 10.1016/j.nbd.2022.105940. Epub 2022 Dec 5. PMID: 36470499; PMCID: PMC10372760.

Who Knew? Dopamine Transporter Activity Is Critical in Innate and Adaptive Immune Responses Gopinath A, Mackie PM, Phan LT, Mirabel R, Smith AR, Miller E, Franks S, Syed O, Riaz T, Law BK, Urs N, Khoshbouei H. Cells. 2023 Jan 10;12(2):269. doi: 10.3390/cells12020269. PMID: 36672204; PMCID: PMC9857305.

DAT and TH expression marks human Parkinson's disease in peripheral immune cells Gopinath A, Mackie P, Hashimi B, Buchanan AM, Smith AR, Bouchard R, Shaw G, Badov M, Saadatpour L, Gittis A, Ramirez-Zamora A, Okun MS, Streit WJ, Hashemi P, Khoshbouei H. NPJ Parkinsons Dis. 2022 Jun 7;8(1):72. doi: 10.1038/s41531-022-00333-8. PMID: 35672374; PMCID: PMC9174333.

Dopamine and norepinephrine are embracing their immune side and so should we Gaskill PJ, Khoshbouei H. Curr Opin Neurobiol. 2022 Dec;77:102626. doi: 10.1016/j.conb.2022.102626. Epub 2022 Sep 1. PMID: 36058009; PMCID: PMC10481402.

Droplet Degeneration of Hippocampal and Cortical Neurons Signifies the Beginning of Neuritic Plaque Formation Streit WJ, Rotter J, Winter K, Müller W, Khoshbouei H, Bechmann I. J Alzheimers Dis. 2022;85(4):1701-1720. doi: 10.3233/JAD-215334. PMID: 34958037.

Functional characterization of the biogenic amine transporters on human macrophages Mackie PM, Gopinath A, Montas DM, Nielsen A, Smith A, Nolan RA, Runner K, Matt SM, McNamee J, Riklan JE, Adachi K, Doty A, Ramirez-Zamora A, Yan L, Gaskill PJ, Streit WJ, Okun MS, Khoshbouei H. JCI Insight. 2022 Feb 22;7(4):e151892. doi: 10.1172/jci.insight.151892. PMID: 35015729; PMCID: PMC8876465.

Levodopa-induced dyskinesia: a historical review of Parkinson's disease, dopamine, and modern advancements in research and treatment Hansen CA, Miller DR, Annarumma S, Rusch CT, Ramirez-Zamora A, Khoshbouei H. J Neurol. 2022 Jun;269(6):2892-2909. doi: 10.1007/s00415-022-10963-w. Epub 2022 Jan 17. PMID: 35039902; PMCID: PMC9124678.

Tumor Treating Fields Suppression of Ciliogenesis Enhances Temozolomide Toxicity Shi P, Tian J, Ulm BS, Mallinger JC, Khoshbouei H, Deleyrolle LP, Sarkisian MR. Front Oncol. 2022 Mar 11;12:837589. doi: 10.3389/fonc.2022.837589. PMID: 35359402; PMCID: PMC8962950.

Activation of proline biosynthesis is critical to maintain glutamate homeostasis during acute methamphetamine exposure Jones B, Balasubramaniam M, Lebowitz JJ, Taylor A, Villalta F, Khoshbouei H, Grueter C, Grueter B, Dash C, Pandhare J. Sci Rep. 2021 Jan 14;11(1):1422. doi: 10.1038/s41598-020-80917-7. PMID: 33446840; PMCID: PMC7809342.

Author Correction: TNFα increases tyrosine hydroxylase expression in human monocytes Gopinath A, Badov M, Francis M, Shaw G, Collins A, Miller DR, Hansen CA, Mackie P, Tansey MG, Dagra A, Madorsky I, Ramirez-Zamora A, Okun MS, Streit WJ, Khoshbouei H. NPJ Parkinsons Dis. 2021 Aug 2;7(1):68. doi: 10.1038/s41531-021-00212-8. Erratum for: NPJ Parkinsons Dis. 2021 Jul 20;7(1):62. doi: 10.1038/s41531-021-00201-x. PMID: 34341346; PMCID: PMC8329045.

Dopamine Transporter Is a Master Regulator of Dopaminergic Neural Network Connectivity Miller DR, Guenther DT, Maurer AP, Hansen CA, Zalesky A, Khoshbouei H. J Neurosci. 2021 Jun 23;41(25):5453-5470. doi: 10.1523/JNEUROSCI.0223-21.2021. Epub 2021 May 12. PMID: 33980544; PMCID: PMC8221606.

Dynamic control of the dopamine transporter in neurotransmission and homeostasis Bu M, Farrer MJ, Khoshbouei H. NPJ Parkinsons Dis. 2021 Mar 5;7(1):22. doi: 10.1038/s41531-021-00161-2. PMID: 33674612; PMCID: PMC7935902.

HDAC6 Signaling at Primary Cilia Promotes Proliferation and Restricts Differentiation of Glioma Cells Shi P, Hoang-Minh LB, Tian J, Cheng A, Basrai R, Kalaria N, Lebowitz JJ, Khoshbouei H, Deleyrolle LP, Sarkisian MR. Cancers (Basel). 2021 Apr 1;13(7):1644. doi: 10.3390/cancers13071644. PMID: 33915983; PMCID: PMC8036575.

Identification of Critical Residues in the Carboxy Terminus of the Dopamine Transporter Involved in the G Protein βγ-Induced Dopamine Efflux Pino JA, Nuñez-Vivanco G, Hidalgo G, Reyes Parada M, Khoshbouei H, Torres GE. Front Pharmacol. 2021 Mar 24;12:642881. doi: 10.3389/fphar.2021.642881. PMID: 33841159; PMCID: PMC8025876.

In Parkinson's patient-derived dopamine neurons, the triplication of α-synuclein locus induces distinctive firing pattern by impeding D2 receptor autoinhibition Lin M, Mackie PM, Shaerzadeh F, Gamble-George J, Miller DR, Martyniuk CJ, Khoshbouei H. Acta Neuropathol Commun. 2021 Jun 7;9(1):107. doi: 10.1186/s40478-021-01203-9. PMID: 34099060; PMCID: PMC8185945.

Methamphetamine Dysregulation of the Central Nervous System and Peripheral Immunity Miller DR, Bu M, Gopinath A, Martinez LR, Khoshbouei H. J Pharmacol Exp Ther. 2021 Dec;379(3):372-385. doi: 10.1124/jpet.121.000767. Epub 2021 Sep 17. PMID: 34535563; PMCID: PMC9351721.

Monogenic Diabetes and Integrated Stress Response Genes Display Altered Gene Expression in Type 1 Diabetes Hiller H, Beachy DE, Lebowitz JJ, Engler S, Mason JR, Miller DR, Kusmarteva I, Jacobsen LM, Posgai AL, Khoshbouei H, Oram RA, Schatz DA, Hattersley AT, Bodenmiller B, Atkinson MA, Nick HS, Wasserfall CH. Diabetes. 2021 Aug;70(8):1885-1897. doi: 10.2337/db21-0070. Epub 2021 May 25. PMID: 34035041; PMCID: PMC8385619.

The Role of Microglia in Sporadic Alzheimer's Disease Streit WJ, Khoshbouei H, Bechmann I. The Role of Microglia in Sporadic Alzheimer's Disease. J Alzheimers Dis. 2021;79(3):961-968. doi: 10.3233/JAD-201248. PMID: 33361603.

TNFα increases tyrosine hydroxylase expression in human monocytes. Gopinath A, Badov M, Francis M, Shaw G, Collins A, Miller DR, Hansen CA, Mackie P, Tansey MG, Dagra A, Madorsky I, Ramirez-Zamora A, Okun MS, Streit WJ, Khoshbouei H. Dis. 2021 Jul 20;7(1):62. doi: 10.1038/s41531-021-00201-x. Erratum in: NPJ Parkinsons Dis. 2021 Aug 2;7(1):68. doi: 10.1038/s41531-021-00212-8. PMID: 34285243; PMCID: PMC8292430.

α-synuclein induced dysregulation of neuronal activity contributes to murine dopamine neuron vulnerability. Abeer Dagra, Douglas R. Miller, Min Lin, Adithya Gopinath, Fatemeh Shaerzadeh, Sharonda Harris, Zachary A. Sorrentino, Jonatan Fullerton Støier, Sophia Velasco, Janelle Azar, Adetola R Alonge, JosephJ Lebowitz, Brittany Ulm, Anthea-MengfeiBu, Carissa A. Hansen, Nikhil Urs, Benoit I. Giasson, Habibeh Khoshbouei. Accepted in NPJ June 2021.

A novel approach to study markers of dopamine signaling in peripheral immune cells. Gopinath A, Doty A, Mackie PM, Hashimi B, Francis M, Saadatpour L, Saha K, Shaw G, Ramirez-Zamora A, Okun MS, Streit WJ, Khoshbouei H. J Immunol Methods. 2019 Oct 18:112686. doi: 10.1016/j.jim.2019.112686. PMID: 31634479

Methamphetamine regulation of activity and topology of ventral midbrain networks. Miller DR, Lebowitz JJ, Guenther DT, Refowich AJ, Hansen C, Maurer AP, Khoshbouei H. PLoS One. 2019 Sep 19;14(9):e0222957. doi: 10.1371/journal.pone.0222957. eCollection 2019. PMID: 31536584

Dopamine increases HIV entry into macrophages by increasing calcium release via an alternative signaling pathway. Nickoloff-Bybel EA, Mackie P, Runner K, Matt SM, Khoshbouei H, Gaskill PJ. Brain Behav Immun. 2019 Aug 27. pii: S0889-1591(19)30115-1. doi: 10.1016/j.bbi.2019.08.191. PMID: 31470080

Elevated bone marrow sympathetic drive precedes systemic inflammation in angiotensin II hypertension. Ahmari N, Santisteban MM, Miller DR, Geis NM, Larkin R, Redler T, Denson H, Khoshbouei H, Baekey DM, Raizada MK, Zubcevic J. Am J Physiol Heart Circ Physiol. 2019 Aug 1;317(2):H279-H289. doi: 10.1152/ajpheart.00510.2018. Epub 2019 May 31. PMID: 31150271

PMP22 Regulates Cholesterol Trafficking and ABCA1-Mediated Cholesterol Efflux. Zhou Y, Miles JR, Tavori H, Lin M, Khoshbouei H, Borchelt DR, Bazick H, Landreth GE, Lee S, Fazio S, Notterpek L. J Neurosci. 2019 Jul 3;39(27):5404-5418. doi: 10.1523/JNEUROSCI.2942-18.2019. Epub 2019 May 6. PMID: 31061090

Clustered Kv2.1 decreases dopamine transporter activity and internalization. Lebowitz JJ, Pino JA, Mackie PM, Lin M, Hurst C, Divita K, Collins AT, Koutzoumis DN, Torres GE, Khoshbouei H. J Biol Chem. 2019 Apr 26;294(17):6957-6971. doi: 10.1074/jbc.RA119.007441. Epub 2019 Mar 1. PMID: 30824538

Methamphetamine neurotoxicity, microglia, and neuroinflammation. Shaerzadeh F, Streit WJ, Heysieattalab S, Khoshbouei H. J Neuroinflammation. 2018 Dec 12;15(1):341. doi: 10.1186/s12974-018-1385-0. Review. PMID: 30541633

Microglial activation occurs late during preclinical Alzheimer's disease. Streit WJ, Braak H, Del Tredici K, Leyh J, Lier J, Khoshbouei H, Eisenlöffel C, Müller W, Bechmann I. Glia. 2018 Dec;66(12):2550-2562. doi: 10.1002/glia.23510. Epub 2018 Nov 11. PMID: 30417428

Prolonged increase in ser31 tyrosine hydroxylase phosphorylation in substantia nigra following cessation of chronic methamphetamine. Salvatore MF, Nejtek VA, Khoshbouei H. Neurotoxicology. 2018 Jul;67:121-128. doi: 10.1016/j.neuro.2018.05.003. Epub 2018 May 18. PMID: 29782882 

Involvement of Neuroinflammation in the Pathogenesis of Monocrotaline-Induced Pulmonary Hypertension. Sharma RK, Oliveira AC, Kim S, Rigatto K, Zubcevic J, Rathinasabapathy A, Kumar A, Lebowitz JJ, Khoshbouei H, Lobaton G, Aquino V, Richards EM, Katovich MJ, Shenoy V, Raizada MK.  Hypertension. 2018 Jun;71(6):1156-1163. doi: 10.1161/HYPERTENSIONAHA.118.10934. PMID: 29712738

HIV-1 Tat regulation of dopamine transmission and microglial reactivity is brain region specific.  Miller DR, Shaerzadeh F, Phan L, Sharif N, Gamble-George J, McLaughlin JP, Streit WJ, Khoshbouei H.  Glia. 2018 May 7. doi: 10.1002/glia.23447.  PMID: 29733459

Functional connectivity, behavioral and dopaminergic alterations 24 hours following acute exposure to synthetic bath salt drug methylenedioxypyrovalerone. Colon-Perez LM, Pino JA, Saha K, Pompilus M, Kaplitz S, Choudhury N, Jagnarine DA, Geste JR, Levin BA, Wilks I, Setlow B, Bruijnzeel AW, Khoshbouei H, Torres GE, Febo M. Neuropharmacology. 2018 May 3;137:178-193. doi: 10.1016/j.neuropharm.2018.04.031.  PMID: 29729891

Glial cells modulate hippocampal synaptic plasticity in morphine dependent rats. Elahi-Mahani A, Heysieattalab S, Hosseinmardi N, Janahmadi M, Seyedaghamiri F, Khoshbouei H. Brain Res Bull. 2018 Apr 17;140:97-106. doi: 10.1016/j.brainresbull.2018.04.006.  PMID: 29678774

Hippocampal glial cells modulate morphine-induced behavioral responses. Seyedaghamiri F, Heysieattalab S, Hosseinmardi N, Janahmadi M, Elahi-Mahani A, Salari F, Golpayegani M, Khoshbouei H. Physiol Behav. 2018 Jul 1;191:37-46. doi: 10.1016/j.physbeh.2018.04.003. Epub 2018 Apr 4. PMID: 29626506

The dopamine transporter: An unrecognized nexus for dysfunctional peripheral immunity and signaling in Parkinson's Disease. Mackie P, Lebowitz J, Saadatpour L, Nickoloff E, Gaskill P, Khoshbouei H. Brain Behav Immun. 2018 Mar 15. pii: S0889-1591(18)30071-0. doi: 10.1016/j.bbi.2018.03.020. PMID: 29551693

The sigma-1 receptor as a regulator of dopamine neurotransmission: A potential therapeutic target for methamphetamine addiction. Sambo DO, Lebowitz JJ, Khoshbouei H. Pharmacol Ther. 2018 Jan 29. pii: S0163-7258(18)30016-0. doi: 10.1016/j.pharmthera.2018.01.009.  PMID: 29360540

The sigma-1 receptor modulates methamphetamine dysregulation of dopamine neurotransmission.  Sambo D, Lin M, Owens A, Lebowitz J, Richardson B, Jagnarine D, Shetty M, Rodriguez M, Alonge T, Ali M, Katz J, Yan L, Febo M, Henry K, Bruijnzeel A, Dawes L, Khoshbouei H. Nat Commun. 2017 Dec 20;8(1):2228. doi:10.1038/s41467-017-02087-x. PMID: 29263318

Methamphetamine Regulation of Firing Activity of Dopamine Neurons.  Lin M, Sambo D, Khoshbouei H. Journal of Neurosci. 2016 Oct 5;36(40):10376-10391. PMID: 27707972

Proteolysis of α-synuclein fibrils in the lysosomal pathway limits induction of inclusion pathology.  Sacino AN, Brooks MM, Chakrabarty P, Saha K, Khoshbouei H, Golde TE, Giasson BI. J Neurochem. 2017 Feb;140(4):662-678. doi: 10.1111/jnc.13743. Epub 2016 Aug 19. PMID: 27424880

Amphetamine Reverses Escalated Cocaine Intake via Restoration of Dopamine Transporter Conformation. Siciliano CA, Saha K, Calipari ES, Fordahl SC, Chen R, Khoshbouei H, Jones SR. J Neurosci. 2018 Jan 10;38(2):484-497. doi: 10.1523/JNEUROSCI.2604-17.2017. Epub 2017 Nov 24. PMID: 29175958

A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking. Khare S, Nick JA, Zhang Y, Galeano K, Butler B, Khoshbouei H, Rayaprolu S, Hathorn T, Ranum LPW, Smithson L, Golde TE, Paucar M, Morse R, Raff M, Simon J, Nordenskjöld M, Wirdefeldt K, Rincon-Limas DE, Lewis J, Kaczmarek LK, Fernandez-Funez P, Nick HS, Waters MF. PLoS One. 2017 May 3;12(5):e0173565. doi: 10.1371/journal.pone.0173565. eCollection 2017. PMID: 28467418 

HIV, Tat and dopamine transmission. Gaskill PJ, Miller DR, Gamble-George J, Yano H, Khoshbouei H. Neurobiol Dis. 2017 Sep;105:51-73. doi: 10.1016/j.nbd.2017.04.015. Epub 2017 Apr 27. Review. PMID: 28457951

Alpha-synuclein modulates dopamine neurotransmission.  Butler B, Sambo D, Khoshbouei H. J Chem Neuroanat. 2016 Jun 19. pii: S0891-0618(16)30068-0. doi: 10.1016/j.jchemneu.2016.06.001. [Epub ahead of print] Review. PMID: 27334403

Methamphetamine-induced enhancement of hippocampal long-term potentiation is modulated by NMDA and GABA receptors in the shell-accumbens.  Heysieattalab S, Naghdi N, Hosseinmardi N, Zarrindast MR, Haghparast A, Khoshbouei H. Synapse. 2016 Aug;70(8):325-35. doi: 10.1002/syn.21905. Epub 2016 Apr 15. PMID: 27029021

Membrane potential shapes regulation of dopamine transporter trafficking at the plasma membrane.  Richardson BD, Saha K, Krout D, Cabrera E, Felts B, Henry LK, Swant J, Zou MF, Newman AH, Khoshbouei H. Nat Commun. 2016 Jan 25;7:10423. doi: 10.1038/ncomms10423. PMID: 26804245

The effects of GABAA and NMDA receptors in the shell-accumbens on spatial memory of METH-treated rats.  Heysieattalab S, Naghdi N, Zarrindast MR, Haghparast A, Mehr SE, Khoshbouei H. Pharmacol Biochem Behav. 2016 Mar;142:23-35. doi: 10.1016/j.pbb.2015.12.008. Epub 2015 Dec 18. PMID: 26708956

Dopamine Transporter Activity Is Modulated by α-Synuclein.  Butler B, Saha K, Rana T, Becker JP, Sambo D, Davari P, Goodwin JS, Khoshbouei H. J Biol Chem. 2015 Dec 4;290(49):29542-54. doi: 10.1074/jbc.M115.691592. Epub 2015 Oct 6. PMID: 26442590

Dopamine Transporter Activity Is Modulated by α-synuclein. Butler B, Goodwin S, Saha K, Becker J, Sambo D, Davari P, Khoshbouei H. J Biol Chem. 2015 Jun 5. pii: jbc.M115.639880. doi: 10.1074/jbc.M115.639880. Epub 2015 Jun 5. Retraction in: J Biol Chem. 2015 Jul 31;290(31):19009. PMID: 26048988

Intracellular Methamphetamine Prevents the Dopamine-induced Enhancement of Neuronal Firing.  Saha K, Sambo D, Richardson BD, Lin LM, Butler B, Villarroel L, Khoshbouei H J Biol Chem. 2014 Aug 8;289(32):22246-57. doi: 10.1074/jbc.M114.563056. Epub 2014 Jun 24. PMID: 25621291

The effect of manganese on dopamine toxicity and dopamine transporter (DAT) in control and DAT transfected HEK cells.  Roth JA, Li Z, Sridhar S, Khoshbouei H. Neurotoxicology. 2013 Mar; 35: 121-8. doi: 10.1016/j.neuro.2013.01.002 Epub 2013 Jan 11. PMID: 23313730

Chronic methamphetamine exposure produces a delayed, long-lasting memory deficit.  North A, Swant J, Salvatore MF, Gamble-George J, Prins P, Butler B, Mittal MK, Heltsley R, Clark JT, Khoshbouei H. Synapse. 2013 May;67(5):245-57. doi: 10.1002/syn.21635. Epub 2013 Feb. 8 PMID: 23280858

Single cell measurement of dopamine release with simultaneous voltage-clamp and amperometry.  Saha K, Swant J, Khoshbouei H. J Vis Exp. 2012 Nov 21;(69). pii: 3798. doi: 10.3791-3798. PMID: 23207721

α-Synuclein Stimulates a Dopamine Transporter-dependent Chloride Current and Modulates the Activity of the Transporter.  Swant J, Goodwin JS, North A, Ali AA, Gamble-George J, Chirwa S, Khoshbouei H.  J Biol Chem. 2011 Dec 23;286(51):43933-43. Epub 2011 Oct 11. PMID: 21990355

Methamphetamine reduces LTP and increases baseline synaptic transmission in the CA1 region of mouse hippocampus.  Swant J, Chirwa S, Stanwood G, Khoshbouei H.  PLoS One. 2010 Jun 30;5(6):e11382. PMID: 20614033

Amphetamine and methamphetamine differentially affect dopamine transporters in vitro and in vivo.  Goodwin JS, Larson GA, Swant J, Sen N, Javitch JA, Zahniser NR, De Felice LJ, Khoshbouei H.  J Biol Chem. 2009 Jan 30;284(5):2978-89. Epub 2008 Dec 1. PMID: 19047053

PI3K signaling supports amphetamine-induced dopamine efflux.  Lute BJ, Khoshbouei H, Saunders C, Sen N, Lin RZ, Javitch JA, Galli A.  Biochem Biophys Res Commun. 2008 Aug 8;372(4):656-61. Epub 2008 May 27. PMID: 18510945

Amphetamine induces dopamine efflux through a dopamine transporter channel. Kahlig KM, Binda F, Khoshbouei H, Blakely RD, McMahon DG, Javitch JA, Galli A.  Proc Natl Acad Sci U S A. 2005 Mar 1;102(9):3495-500. Epub 2005 Feb 22. PMID: 15728379

Chronic Methamphetamine Increases Alpha-Synuclein Protein Levels in the Striatum and Hippocampus but not in the Cortex of Juvenile Mice. Butler B, Gamble-George J, Prins P, North A, Clarke JT, Khoshbouei H. J Addict Prev. 2014;2(2). pii: 6. PMID: 25621291

PAH particles perturb prenatal processes and phenotypes: protection from deficits in object discrimination afforded by dampening of brain oxidoreductase following in utero exposure to inhaled benzo(a)pyrene. Li Z, Chadalapaka G, Ramesh A, Khoshbouei H, Maguire M, Safe S, Rhoades RE, Clark R, Jules G, McCallister M, Aschner M, Hood DB. Toxicol Sci. 2012 Jan;125(1):233-47. doi: 10.1093/toxsci/kfr261. Epub 2011 Oct 10. PMID: 21987461

Prenatal exposure to benzo(a)pyrene impairs later-life cortical neuronal function. McCallister MM, Maguire M, Ramesh A, Aimin Q, Liu S, Khoshbouei H, Aschner M, Ebner FF, Hood DB. Neurotoxicology. 2008 Sep;29(5):846-54. doi: 10.1016/j.neuro.2008.07.008. Epub 2008 Aug 9. PMID: 18761371

Calmodulin kinase II interacts with the dopamine transporter C terminus to regulate amphetamine-induced reverse transport. Fog JU, Khoshbouei H, Holy M, Owens WA, Vaegter CB, Sen N, Nikandrova Y, Bowton E, McMahon DG, Colbran RJ, Daws LC, Sitte HH, Javitch JA, Galli A, Gether U. Neuron. 2006 Aug 17;51(4):417-29. PMID: 16908408

Intracellular Ca2+ regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine transporter. Gnegy ME, Khoshbouei H, Berg KA, Javitch JA, Clarke WP, Zhang M, Galli A. Mol Pharmacol. 2004 Jul;66(1):137-43. PMID: 15213305

N-terminal phosphorylation of the dopamine transporter is required for amphetamine-induced efflux. Khoshbouei H, Sen N, Guptaroy B, Johnson L', Lund D, Gnegy ME, Galli A, Javitch JA. PLoS Biol. 2004 Mar;2(3):E78. Epub 2004 Mar 16. PMID: 15024426

Interactions of norepinephrine and galanin in the central amygdala and lateral bed nucleus of the stria terminalis modulate the behavioral response to acute stress. Morilak DA, Cecchi M, Khoshbouei H. Life Sci. 2003 Jun 27;73(6):715-26. Review. PMID: 12801593

Amphetamine-induced dopamine efflux. A voltage-sensitive and intracellular Na+-dependent mechanism. Khoshbouei H, Wang H, Lechleiter JD, Javitch JA, Galli A. J Biol Chem. 2003 Apr 4;278(14):12070-7. Epub 2003 Jan 29. PMID: 12556446

Modulatory effects of norepinephrine, acting on alpha 1 receptors in the central nucleus of the amygdala, on behavioral and neuroendocrine responses to acute immobilization stress. Cecchi M, Khoshbouei H, Morilak DA. Neuropharmacology. 2002 Dec;43(7):1139-47. PMID: 12504920

Modulatory effects of galanin in the lateral bed nucleus of the stria terminalis on behavioral and neuroendocrine responses to acute stress. Khoshbouei H, Cecchi M, Morilak DA. Neuropsychopharmacology. 2002 Jul;27(1):25-34. PMID: 12062904

Modulatory effects of norepinephrine in the lateral bed nucleus of the stria terminalis on behavioral and neuroendocrine responses to acute stress. Cecchi M, Khoshbouei H, Javors M, Morilak DA. Neuroscience. 2002;112(1):13-21. PMID: 12044468

Behavioral reactivity to stress: amplification of stress-induced noradrenergic activation elicits a galanin-mediated anxiolytic effect in central amygdala. Khoshbouei H, Cecchi M, Dove S, Javors M, Morilak DA. Pharmacol Biochem Behav. 2002 Mar;71(3):407-17. PMID: 11830175

Molecular characterization and expression of cloned human galanin receptors GALR2 and GALR3. Kolakowski LF Jr, O'Neill GP, Howard AD, Broussard SR, Sullivan KA, Feighner SD, Sawzdargo M, Nguyen T, Kargman S, Shiao LL, Hreniuk DL, Tan CP, Evans J, Abramovitz M, Chateauneuf A, Coulombe N, Ng G, Johnson MP, Tharian A, Khoshbouei H, George SR, Smith RG, O'Dowd BF. J Neurochem. 1998 Dec;71(6):2239-51. PMID: 9832121

Microglia Senescence Occurs in Both Substantia Nigra and Ventral Tegmental Area Shaerzadeh F, Phan L, Miller D, et al. Microglia senescence occurs in both substantia nigra and ventral tegmental area [published online ahead of print, 2020 Apr 10]. Glia. 2020;10.1002/glia.23834. doi:10.1002/glia.23834 PMID: 32275335

Microglia and other myeloid cells in CNS health and disease Adithya Gopinath, Anthony Collins, Habibeh Khoshbouei and Wolfgang Streit Journal of Pharmacology and Experimental Therapeutics April 1, 2020, jpet.120.265058; DOI: https://doi.org/10.1124/jpet.120.265058

A novel approach to study markers of dopamine signaling in peripheral immune cells Adithya Gopinath, Andria Doty, Phillip M Mackie, Basil Hashimi, Madison Francis, Leila Saadatpour, Kaustuv Saha, Gerry Shaw, Adolfo Ramirez-Zamora , Michael S Okun, Wolfgang J Streit, Habibeh Khoshbouei  J Immunol Methods. 2020;476:112686. doi:10.1016/j.jim.2019.112686 PMID: 31634479